The 2025 ISPE Annual Meeting & Expo is poised to herald a transformative era in pharmaceutical science and manufacturing. A key topic of this year's conference will be Pharma 4.0, focusing on the end-to-end implementation of digitalization across all stages of project execution, manufacturing, and regulatory processes. The increasing impact of new technologies, such as artificial intelligence (AI), machine learning (ML), and automation, is sparking interest in many areas of development and CMC, fundamentally reshaping the pharmaceutical industry’s future.